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Levothyroxine shows no benefit in elderly patients with subclinical hypothyroidism, trial finds

BMJ 2017; 357 doi: https://doi.org/10.1136/bmj.j1754 (Published 06 April 2017) Cite this as: BMJ 2017;357:j1754
  1. Susan Mayor
  1. London

Treatment with levothyroxine provides no clinical benefit in older people with subclinical hypothyroidism, a UK randomised trial published in the New England Journal of Medicine has shown.1

Subclinical hypothyroidism, defined as an elevated serum thyrotropin level and a serum free thyroxine level within the reference range, is common in older people, affecting 8-18% of over 65s. It is more common in women than men.

Thyroid hormones have a wide …

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